Crystallization Microplates
Cayman Chemical IvermectIn B1a aglycon 5mg
An immediate precursor used in the biosynthesis by glucose addition of storage polysaccharides in plants green algae and cyanobacteria as well as structural polysaccharides in certain bacteria
Cayman Chemical AvermectIn B1a 1mg
ABlactamase inhibitor that is effective against Ambler class ABlactamases (IC50 values range from 12 to 60 nM) commonly used with other antibiotics that would be inactivated byBlactamases
Cayman Chemical epI-IvermectIn B1a 5mg
An integrin aVB3 receptor antagonist inhibits adhesion and induces apoptosis of U87MG and U373MG but not U251MG cells that lack the integrin aVB3 receptor in vitro at a concentration of 20 g/ml delays tumor implantation time reduces tumor growth and prolongs survival in a U87MG mouse model of glioblastoma when administered at a dose of 200 g/animal per day
Cayman Chemical 2-AvermectIn B1a 5mg
An inhibitor of P-gp selectively reverses multidrug resistance mediated by P-gp over MRP1- and BCRP-mediated multidrug resistance resensitizes SKOV3TR and OVCAR-8TR cells to paclitaxel reverses P-gp efflux increasing the intracellular accumulation of P-gp substrates in multidrug resistant SKOV3TR and OVCAR-8TR cells prevents paclitaxel-induced overexpression of MDR1 and P-gp protein level increases in OVCAR-8 cells prevents the development of paclitaxel-induced multidrug resistance in a SKOV3 mouse xenograft model at 50 mg/kg per day in combination with paclitaxel
Cayman Chemical AvermectIn B1a aglycon 5mg
A turn-on fluorescent probe for lipid radicals upon reaction with lipid radicals displays excitation/emission maxima of 470/530 nm respectively selective for lipid radicals over peroxide oxygen hypochlorite and hydroxy radicals in cell-free assays has been used in the detection of lipid radicals in in vitro and in vivo models of hepatocellular carcinoma and oxidative disease
Molecular Dimensions MEMSTART + MEMSYS HT-96
Protein Crystallography. MEMSTART + MEMSYS Screen HT-96 (96 x 1.1mL) For transmembrane proteins using vapour diffusion methods, allows the pH range, precipitants and salts used in membrane protein crystallization to be screened with detergent- containing protein drop.
Mitegen MicroLoop LD Assembly; box of 20 assemblies, 50 micron MicroLoops LD, 20 mounts on 18mm/SPINE length rods adhered into B5 bases.
MiTeGen offers ready-to-use assemblies for cryocrystallography. This page offers assemblies of Dual Thickness MicroLoopLD™ (M5) styles epoxied into the B5 Goniometer Bases. These assemblies are ideal for standard lab use or high-throughput applications. Each pack consists of 20 mounts epoxied into the goniometer bases, carefully loaded into our base holder and case.
Molecular Dimensions UV HANGING DROP SHEETS (100)
UV HANGING DROP SHEETS (100) Hanging-drop sheets with 96 round wells for easy positioning of crystallization drops for hanging-drop experiments.
Cayman Chemical EprInomectIn B1a 1mg
A potent inhibitor of Cdc7 (IC50 3 4 nM) 60 10 and 300-fold selective for Cdc7 over CK2 PIM1 and a panel of over 100 protein kinases respectively inhibits the growth of MDA-MB-231T and COLO 205 cells (IC50s 118 and 140 nM respectively) inhibits Cdc7-specific phosphorylation of MCM2 and induces cell cycle accumulation in the S and G2 phases in MDA-MB-231T and COLO 205 cells inhibits MCM2 phosphorylation (ED50 3 mg/kg) and reduces tumor growth in a COLO 205 mouse xenograft model at 10 30 and 100 mg/kg
Cayman Chemical AvRmectIn B1a monsaccharID 1mg
A synthetic glucocorticoid with anti-inflammatory properties inhibits edema by 55 in a RPA test in rabbit when administered topically (0.1 w/w) inhibits edema by 70.1 and 88.0 in croton oil-induced and PCA tests respectively in rat (topical 0.1 w/w) in vivo application (0.1 w/w) to the abraded surface of cecum in rats inhibits leukocyte adhesion (43.3 incidence versus 100 for controls) and lowers the total number of intraperitoneal leukocytes from 270 million to 121 million 3 days post surgery acts as an agonist at the Smo receptor (EC50 1100 nM)
Cayman Chemical IvermectIn B1a 5mg
A peptide antagonist of PAR2 which blocks activation by trypsin (IC50 ~50 M) but not by the synthetic agonist SLIGRL-NH2 does not affect thrombin-induced activation of PAR1 or trypsin-mediated proteolysis of casein used to study PAR2 action in cells and in animals
Cayman Chemical EmamectIn B1a 5mg
An orally bioavailable and ATP-competitive multi-AGC kinase inhibitor inhibits Akt1 2 and 3 (IC50s 38 402 and 50 nM respectively) inhibits p70S6K PKA and ROCK1 and ROCK2 (IC50s 3-8 nM) antiproliferative against cancer cell lines with genetic mutations in PI3K-Akt-mTOR or RAS-RAF pathways (GI50s 1.54-3.77 M) inhibits growth of MES-SA uterine sarcoma and BT474 breast cancer xenografts in mice (50 mg/kg p.o.) inhibits ROCK-dependent phosphorylation of MLC2 over a 24-hour period in 4599 mouse melanoma cells (EC50 0.1 M) reduces motility of 4699 melanoma cells in murine xenograft model
Cayman Chemical AvRmectIn B1a monsaccharID 5mg
A synthetic glucocorticoid with anti-inflammatory properties inhibits edema by 55 in a RPA test in rabbit when administered topically (0.1 w/w) inhibits edema by 70.1 and 88.0 in croton oil-induced and PCA tests respectively in rat (topical 0.1 w/w) in vivo application (0.1 w/w) to the abraded surface of cecum in rats inhibits leukocyte adhesion (43.3 incidence versus 100 for controls) and lowers the total number of intraperitoneal leukocytes from 270 million to 121 million 3 days post surgery acts as an agonist at the Smo receptor (EC50 1100 nM)
Cayman Chemical 2-AvermectIn B1a 1mg
An inhibitor of P-gp selectively reverses multidrug resistance mediated by P-gp over MRP1- and BCRP-mediated multidrug resistance resensitizes SKOV3TR and OVCAR-8TR cells to paclitaxel reverses P-gp efflux increasing the intracellular accumulation of P-gp substrates in multidrug resistant SKOV3TR and OVCAR-8TR cells prevents paclitaxel-induced overexpression of MDR1 and P-gp protein level increases in OVCAR-8 cells prevents the development of paclitaxel-induced multidrug resistance in a SKOV3 mouse xenograft model at 50 mg/kg per day in combination with paclitaxel
